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RGS16 regulated by let-7c-5p promotes glioma progression by activating PI3K-AKT pathway
《医学前沿(英文)》 2023年 第17卷 第1期 页码 143-155 doi: 10.1007/s11684-022-0929-y
Temporal and spatial stability of the EM/PM molecular subtypes in adult diffuse glioma
《医学前沿(英文)》 2023年 第17卷 第2期 页码 240-262 doi: 10.1007/s11684-022-0936-z
关键词: glioma progression molecular classification EM/PM subtyping intratumor heterogeneity
Aldolase B attenuates clear cell renal cell carcinoma progression by inhibiting CtBP2
《医学前沿(英文)》 2023年 第17卷 第3期 页码 503-517 doi: 10.1007/s11684-022-0947-9
《医学前沿(英文)》 doi: 10.1007/s11684-023-1017-7
关键词: single-cell RNA-seq glioma radial glia primitive oligodendrocyte precursor cell immune escape
Zhaoshi Bao, Yongzhi Wang, Qiangwei Wang, Shengyu Fang, Xia Shan, Jiguang Wang, Tao Jiang
《医学前沿(英文)》 2021年 第15卷 第4期 页码 551-561 doi: 10.1007/s11684-020-0760-2
关键词: glioma evolution mechanism strategies tumor heterogeneity secondary glioma
Lateral progression of brachial plexus avulsion injury
GU Yudong
《医学前沿(英文)》 2007年 第1卷 第1期 页码 20-23 doi: 10.1007/s11684-007-0004-8
null
《医学前沿(英文)》 2016年 第10卷 第1期 页码 33-40 doi: 10.1007/s11684-016-0431-5
Breast cancer is the most common malignant tumor in women, and the incidence of this disease has increased in recent years because of changes in diet, living environment, gestational age, and other unknown factors. Previous studies focused on cancer cells, but an increasing number of recent studies have analyzed the contribution of cancer microenvironment to the initiation and progression of breast cancer. Cancer-associated fibroblasts (CAFs), the most abundant cells in tumor stroma, secrete various active biomolecules, including extracellular matrix components, growth factors, cytokines, proteases, and hormones. CAFs not only facilitate the initiation, growth, angiogenesis, invasion, and metastasis of cancer but also serve as biomarkers in the clinical diagnosis, therapy, and prognosis of breast cancer. In this article, we reviewed the literature and summarized the research findings on CAFs in breast cancer.
关键词: cancer-associated fibroblast breast cancer progression prognosis
4-1BBL expressed by eukaryotic cells activates immune cells and suppresses the progression of murine
Hui QIU, Hui ZHANG, Zuohua FENG
《医学前沿(英文)》 2009年 第3卷 第1期 页码 20-25 doi: 10.1007/s11684-009-0006-9
关键词: 4-1BB ligand tumor immunotherapy tumor microenvironment
Coronary leukocyte activation in relation to progression of coronary artery disease
null
《医学前沿(英文)》 2016年 第10卷 第1期 页码 85-90 doi: 10.1007/s11684-016-0435-1
Leukocyte activation has been linked to atherogenesis, but there is little in vivo evidence for its role in the progression of atherosclerosis. We evaluated the predictive value for progression of coronary artery disease (CAD) of leukocyte activation markers in the coronary circulation. Monocyte and neutrophil CD11b, neutrophil CD66b expression and intracellular neutrophil myeloperoxidase (MPO) in the coronary arteries were determined by flow cytometry in patients undergoing coronary angiography. The primary outcome included fatal and nonfatal myocardial infarction or arterial vascular intervention due to unstable angina pectoris. In total 99 subjects who were included, 70 had CAD at inclusion (26 patients had single-vessel disease, 18 patients had two-vessel disease and 26 patients had three-vessel disease). The median follow-up duration was 2242 days (interquartile range: 2142–2358). During follow-up, 13 patients (13%) developed progression of CAD. Monocyte CD11b, neutrophil CD11b and CD66b expression and intracellular MPO measured in blood obtained from the coronary arteries were not associated with the progression of CAD. These data indicate that coronary monocyte CD11b, neutrophil CD11b and CD66b expression and intracellular MPO do not predict the risk of progression of CAD.
关键词: coronary artery disease inflammation integrin myeloperoxidase leukocyte activation
《医学前沿(英文)》 2023年 第17卷 第3期 页码 476-492 doi: 10.1007/s11684-022-0966-6
关键词: EIF4A1 G-quadruplex hepatocellular carcinoma tRNA-derived small RNA translation initiation
NETO2 promotes melanoma progression via activation of the Ca/CaMKII signaling pathway
《医学前沿(英文)》 2023年 第17卷 第2期 页码 263-274 doi: 10.1007/s11684-022-0935-0
关键词: melanoma neuropilin and tolloid-like 2 Ca2+/CaMKII signaling pathway
DU Xiang, ZHAO Hongguang, GUO Wei, GONG Shouliang, WANG Wen
《医学前沿(英文)》 2008年 第2卷 第2期 页码 204-206 doi: 10.1007/s11684-008-0039-5
null
《医学前沿(英文)》 2014年 第8卷 第1期 页码 106-112 doi: 10.1007/s11684-014-0307-5
Cervical carcinoma is associated with high propensity for local invasion and lymph node metastasis. However, the molecular alterations that drive progression and metastasis of cervical cancer remain unclear. Cellular senescence has been proposed as the mechanism that protects an organism against cancer progression and metastasis. In addition, Twist, a basic helix-loop-helix transcription factor, has been suggested as an oncogene because it is overexpressed in many types of human cancer. This gene also exhibits a positive function in regulating invasion and metastasis. In this study, Twist was strongly and positively expressed in normal tissue, squamous cell carcinoma (SCC) IA--IIA, and SCC IIB--IIIB (4.3%, 44%, and 88.9%, respectively). The strong positive expressions of the senescence marker CBX3 were 39.1%, 32%, and 15.6%, respectively. The strong positive expressions of Twist in the SCC groups with or without lymph node metastasis were 80.8% and 50%. For CBX3, such expressions were 7.7% and 29.5%, respectively. Results also showed that the expression of Twist was inversely correlated with that of CBX3. Moreover, the knockdown of Twist with target siRNA in SiHa triggered the induction of the chromatin marker of the cellular senescence CBX3 and senescence-associated β-galactosidase activity. Our results suggested that the expression of Twist increased during the progression and metastasis of cervical cancer. Furthermore, Twist-induced senescence bypass is important in this process.
关键词: cervical cancer senescence Twist CBX3 lymph node metastasis
Long noncoding RNA LOC646029 functions as a ceRNA to suppress ovarian cancer progression through the
《医学前沿(英文)》 页码 924-938 doi: 10.1007/s11684-023-1004-z
关键词: ovarian cancer lncRNA LOC646029 metastasis microRNA 627-3p SPRED1
Construction of 6HRE-GFAP-Baxα system specific for glioma gene therapy
TIAN Yongji, LI Guilin, GAO Jun, WANG Renzhi, KONG Yanguo, ZHANG Zhenxing, LI Shifang, TIAN Shiqiang, DOU Wanchen, ZHANG Bo
《医学前沿(英文)》 2007年 第1卷 第1期 页码 49-53 doi: 10.1007/s11684-007-0010-x
标题 作者 时间 类型 操作
Distinct immune escape and microenvironment between RG-like and pri-OPC-like glioma revealed by single-cell
期刊论文
Intratumor heterogeneity, microenvironment, and mechanisms of drug resistance in glioma recurrence and
Zhaoshi Bao, Yongzhi Wang, Qiangwei Wang, Shengyu Fang, Xia Shan, Jiguang Wang, Tao Jiang
期刊论文
Breast cancer-associated fibroblasts: their roles in tumor initiation, progression and clinical applications
null
期刊论文
4-1BBL expressed by eukaryotic cells activates immune cells and suppresses the progression of murine
Hui QIU, Hui ZHANG, Zuohua FENG
期刊论文
5′-tiRNA-Gln inhibits hepatocellular carcinoma progression by repressing translation through the interaction
期刊论文
Effects of 3-aminobenzamide on poly (ADP-ribose) polymerase expression, apoptosis and cell cycle progression
DU Xiang, ZHAO Hongguang, GUO Wei, GONG Shouliang, WANG Wen
期刊论文
Correlation of Twist upregulation and senescence bypass during the progression and metastasis of cervical
null
期刊论文
Long noncoding RNA LOC646029 functions as a ceRNA to suppress ovarian cancer progression through the
期刊论文